Epithelial dysfunction in chronic respiratory diseases, a shared endotype?
B Steelant - Current opinion in pulmonary medicine, 2020 - journals.lww.com
Current opinion in pulmonary medicine, 2020•journals.lww.com
… Epithelial barrier defects are being appreciated in various inflammatory disorders; however,
causal underlying mechanisms are lacking. In this review, we describe the disruption of the
airway epithelium with regard to upper and lower airway diseases, the role of epigenetic
alterations underlying this process, and potential novel ways of interfering with dysfunctional
epithelial barriers as a novel therapeutic approach. … In this review, we provide an overview
of airway diseases associated with epithelial barrier defects, indicate possible novel insights …
causal underlying mechanisms are lacking. In this review, we describe the disruption of the
airway epithelium with regard to upper and lower airway diseases, the role of epigenetic
alterations underlying this process, and potential novel ways of interfering with dysfunctional
epithelial barriers as a novel therapeutic approach. … In this review, we provide an overview
of airway diseases associated with epithelial barrier defects, indicate possible novel insights …
Summary
A better understanding of the role of epigenetics in driving and maintaining epithelial defects in various inflammatory diseases, using state-of-the-art biology tools will be crucial in designing novel therapies to protect or reconstitute a defective airway epithelial barrier.
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